Managing MASH: How patients can slow liver disease progression

Metabolic dysfunction-associated steatohepatitis (MASH) develops when excess fat builds up in the liver. The condition requires careful management, but a mix of lifestyle changes, medical treatments, and regular monitoring can help slow or even reverse its progression. Patients working closely with healthcare teams often find ways to improve their liver health and overall well-being.

A diagnosis of MASH can feel overwhelming, but taking proactive steps makes a difference. Doctors often recommend routine tests to track liver health, including blood work, imaging scans like FibroScan® or MRE-PDFF, and sometimes a liver biopsy. These checks help monitor disease progression and guide treatment decisions.

Lifestyle adjustments play a key role in managing the condition. Adopting a Mediterranean diet, exercising regularly, keeping a healthy weight, and prioritising good sleep all support liver function. Avoiding alcohol and smoking further reduces strain on the organ.

Medications also form part of the treatment plan. Drugs such as Resmetiron (RezdiffraTM) and Semaglutide (WegovyTM) have shown promise in slowing fibrosis or even reversing liver damage. For some patients, clinical trials provide access to new therapies not yet widely available. These studies follow strict protocols, and participants may receive either the treatment or a placebo.

Care for MASH often involves a team of specialists. Hepatologists, endocrinologists, cardiologists, dietitians, and primary care providers collaborate to create a unified approach. Their combined expertise ensures patients receive well-rounded support, from medical interventions to dietary advice. Scheduling regular appointments and staying on top of tests helps keep the condition under control.

While no German-specific clinical trials for MASH were identified, international research—such as the Phase 3 semaglutide trial by the ESSENCE Study Group—continues to explore new options. Charité Berlin also studies related liver conditions in lab settings. For now, patients benefit most from a mix of medical care, lifestyle changes, and ongoing monitoring to manage their health effectively.